Lamia (220 km from Athens), a bustling commercial city and capital of the prefecture, is built up the southwest, pine-covered slopes of Mt. Othris near Sperhios river. Dominating the city from a hill above, a Frankish castle rises from the stones of the ancient acropolis. On another hill stands the 18th century Church of Agios Loukas (around late 19th - early 20th century), with a magnificent view of the Maliac gulf and beyond to the shores of Evia.

During your stay here, make it a point to try the local home-made egg noodles, "kourambiedes" (which are crushed almond cookies with sugar powder) and "trachana" (a form of dumpling).

The historic Thermopylae (Thermopiles) pass lies 18 km southeast of Lamia. The statue of Leonidas and the cenotaph of his 300 Spartans remind one of the heroic 480 BC battle. The famous since antiquity thermal springs of Thermopylae, bubbling quite near, have made an important resort out of the village. At a distance of 3 km, stands the historic bridge of Alamana.

Kamena Vourla, to the north, is a popular spa-resort, renowned for its therapeutic waters and dry climate. The coastal towns of the area Agios Konstantinos, Arkitsa —connected by ferry with Edipsos on Evia—as well as the lovely beaches of Aspronerio, Agios Serafim and Agios Nikolaos are pleasant places to spend a holiday especially for those who like swimming and dining on fresh fish.

Atalanti, commercial and agricultural centre of the area. Further west of Atalanti one can visit Elatia and Tithorea, wooded areas of archaeological interest, as well as Amfiklia one of the starting points for going up to the Parnassos ski centre.

Loutra Ipatis, identified with the town itself, is an important spa equipped with hotel and tourism installations.